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Papers of the Week


Papers: 28 May 2022 - 3 Jun 2022


Pharmacology/Drug Development


2022


J Inflamm Res


15

The κ-Opioid Receptor Agonist U50488H Ameliorates Neuropathic Pain Through the Ca/CaMKII/CREB Pathway in Rats.

Authors

Zhang X-M, Lun M-H, DU W, Ma F, Huang Z-Q
J Inflamm Res. 2022; 15:3039-3051.
PMID: 35645576.

Abstract

To observe the ameliorative effect of kappa opioid receptor (KOR) agonist on rats with neuropathic pain (NP) and investigate the mechanism of action of the calcium ion (Ca)/calcium/calmodulin-dependent protein kinase II (CaMKII)/cyclic AMP response element-binding protein (CREB) pathway.