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Papers of the Week

Papers: 28 May 2022 - 3 Jun 2022

Pharmacology/Drug Development

2022 May 23

Curr Pharmacol Rep

Cellular and Molecular Machinery of Neuropathic Pain: an Emerging Insight.


Ameenudeen S, Kashif M, Banerjee S, Srinivasan H, Pandurangan A K, Waseem M
Curr Pharmacol Rep. 2022 May 23:1-9.
PMID: 35646513.


Neuropathic pain (NP) has been ubiquitously characterized by lesion and its linked somatosensory system either the central nervous system (CNS) or peripheral nervous system (PNS) This PNS episode is the most prevalent site of NP origin and is found to be associated with afferent nerve fibers carrying pain signals from injured/trauma site to the CNS including the brain. Several kinds of pharmacotherapeutic drugs shuch as analgesics, anti-convulsants, and anti-depressants are being employed for the its possible interventions. The NP has been a great interest to follow different pathophysiological mechanisms which are often considered to correlate with the metabolic pathways and its mediated disease. There is paucity of knowledge to make such mechanism via NP.