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Papers of the Week

Papers: 28 May 2022 - 3 Jun 2022

Pharmacology/Drug Development

2022 May 30

BMC Musculoskelet Disord



Knockdown of PAR2 alleviates cancer-induced bone pain by inhibiting the activation of astrocytes and the ERK pathway.


Tang Y T, Chen Y, Yang M, Zheng Q, Li Y, Bao Y
BMC Musculoskelet Disord. 2022 May 30; 23(1):514.
PMID: 35637468.


Cancer-induced bone pain (CIBP) is a kind of pain with complex pathophysiology. Proteinase-activated receptor 2 (PAR-2) is involved in CIBP. This study explored the effects of PAR-2 on CIBP rats.