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Papers of the Week


2022


Cancer Manag Res


14

Acute Mast Cell Leukemia Preceded by Malignant Mediastinal Germ Cell Tumor: A Case Report and Literature Review.

Authors

Wang H, Chen Y, Lin H, Ni W, Zhang Q, Lan J, Jin L
Cancer Manag Res. 2022; 14:1783-1794.
PMID: 35637940.

Abstract

Mast cell leukemia (MCL) is a highly life-threatening and extremely rare subtype of systemic mastocytosis (SM). MCL often genetically contains one or more somatic mutations, particularly activating mutations of . This study reported on an acute MCL patient who had a rare phenotype and genetic mutants with a history of primary malignant mediastinal germ cell tumor (GCT).