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Papers of the Week

2022 May 05

Brain Sci



Post-Stroke Asymmetric Prurigo Nodularis Responding to Dupilumab Treatment: A Case Report.


Sammarra I, Bennardo L, Provenzano E, Patruno C, Nisticò S P
Brain Sci. 2022 May 05; 12(5).
PMID: 35624992.


Prurigo nodularis (PN) is a dermatological condition characterized by nodular hyperkeratotic lesions mainly on the legs and arms. Asymmetrical PN is a rare dermatological condition often associated with paralysis and stroke. In this paper, we present the case of a 77-year-old woman who developed post-ictal PN which responded to dupilumab, an anti-interleukin-4/13 drug approved for the management of AD, with an extreme reduction in itch sensation. Dupilumab and other therapies reducing Th2 inflammation may, in the future, become an alternative treatment for post-ictal pruritus/PN nonresponding to traditional therapies. Of course, larger studies will be necessary to confirm our case's findings.