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Papers of the Week

2022 Apr 20

Diagnostics (Basel)



The Role of Urinary VEGF in Observational Studies of BPS/IC Patients: A Systematic Review.


Abreu-Mendes P, Costa A, Charrua A, Pinto R A, Cruz F
Diagnostics (Basel). 2022 Apr 20; 12(5).
PMID: 35626193.


Bladder pain syndrome/interstitial cystitis (BPS/IC) is a chronic pain condition, often underdiagnosed, with an important impact on patient quality of life. More recently, an association between VEGF and its receptors has been suggested in BPS/IC pathophysiology, due to their role in promoting angiogenesis and inflammation, which can enhance bladder pain. Eventually, VEGF may be used as a biomarker for the diagnosis and prognostication of BPS/IC. To further clarify this issue, this review aims to critically summarize the available information, giving rise to a solid starting point for future studies.