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Papers of the Week


2022 May 21


Pharmaceutics


14


5

Impact of Magnesium on Oxytocin Receptor Function.

Authors

Bharadwaj VN, Meyerowitz J, Zou B, Klukinov M, Yan N, Sharma K, Clark DJ, Xie X, Yeomans DC
Pharmaceutics. 2022 May 21; 14(5).
PMID: 35631690.

Abstract

The intranasal administration of oxytocin (OT) reduces migraine headaches through activation of the oxytocin receptor (OTR). Magnesium ion (Mg concentration is critical to the activation of the OTR, and a low serum Mg concentration is predictive of a migraine headache. We, therefore, examined the functional impact of Mg concentration on OT-OTR binding efficacy using two complimentary bioassays.