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Papers of the Week

2022 May 21




Impact of Magnesium on Oxytocin Receptor Function.


Bharadwaj VN, Meyerowitz J, Zou B, Klukinov M, Yan N, Sharma K, Clark DJ, Xie X, Yeomans DC
Pharmaceutics. 2022 May 21; 14(5).
PMID: 35631690.


The intranasal administration of oxytocin (OT) reduces migraine headaches through activation of the oxytocin receptor (OTR). Magnesium ion (Mg concentration is critical to the activation of the OTR, and a low serum Mg concentration is predictive of a migraine headache. We, therefore, examined the functional impact of Mg concentration on OT-OTR binding efficacy using two complimentary bioassays.