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2022 May 21
Pharmaceutics
14
5
The intranasal administration of oxytocin (OT) reduces migraine headaches through activation of the oxytocin receptor (OTR). Magnesium ion (Mg concentration is critical to the activation of the OTR, and a low serum Mg concentration is predictive of a migraine headache. We, therefore, examined the functional impact of Mg concentration on OT-OTR binding efficacy using two complimentary bioassays.