I am a
Home I AM A Search Login

Papers of the Week

Papers: 28 May 2022 - 3 Jun 2022

Animal Studies

2022 May-Jun

Pain Rep



Fadu head and neck squamous cell carcinoma induces hyperexcitability of primary sensory neurons in an in vitro coculture model.


Uhelski ML, Gorur A, Shi T, Corrales G, Du KN, Li Y, Amit M, Tatsui CE, Rhines LD, Dougherty PM, Cata JP
Pain Rep. 2022 May-Jun; 7(3):e1012.
PMID: 35620249.


Currently, cancer pain is viewed as a process orchestrated by the release of pronociceptive molecules and the invasion of neural structures, referred to as perineural invasion (PNI). Cancer pain resulting from PNI is well-documented, but the mechanisms leading to peripheral sensitization because of tumor growth are not fully known.