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Papers of the Week


Papers: 21 May 2022 - 27 May 2022


Human Studies, Pharmacology/Drug Development


2022 May 25


Pain Ther

Food-Specific IgG4 Antibody-Guided Exclusion Diet Improves Conditions of Patients with Chronic Pain.

Authors

Casini I, Fatighenti E, Giannantoni A, Massai L, Pieretti S, Ceccarelli I, Aloisi A M
Pain Ther. 2022 May 25.
PMID: 35612757.

Abstract

Chronic pain is related to gastrointestinal (GI) functions because food components affect inflammation and pain through their action on the GI immune and/or neural system and because many analgesics interact with the gut to alter its structure and function. Immunoglobulin G4 (IgG4) are food-specific antibodies resulting from exposure of the gut immune system to nutrients. High IgG4 levels have been found to be associated with inflammation.