I am a
Home I AM A Search Login

Papers of the Week

Papers: 21 May 2022 - 27 May 2022

Human Studies, Pharmacology/Drug Development

2022 May 25

Pain Ther

Food-Specific IgG4 Antibody-Guided Exclusion Diet Improves Conditions of Patients with Chronic Pain.


Casini I, Fatighenti E, Giannantoni A, Massai L, Pieretti S, Ceccarelli I, Aloisi A M
Pain Ther. 2022 May 25.
PMID: 35612757.


Chronic pain is related to gastrointestinal (GI) functions because food components affect inflammation and pain through their action on the GI immune and/or neural system and because many analgesics interact with the gut to alter its structure and function. Immunoglobulin G4 (IgG4) are food-specific antibodies resulting from exposure of the gut immune system to nutrients. High IgG4 levels have been found to be associated with inflammation.