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Papers of the Week

Papers: 21 May 2022 - 27 May 2022

Animal Studies

2022 May 19

Life Sci

Melatonin mediated inhibition of EZH2-NOS2 crosstalk attenuates inflammatory bowel disease in preclinical in vitro and in vivo models.


Sardoiwala M N, Mohanbhai S J, Kushwaha A C, Dev A, Biswal L, Sharma S S, Choudhury S R, Karmakar S
Life Sci. 2022 May 19:120655.
PMID: 35598656.


Inflammatory Bowel Disease is characterised by abdominal pain, diarrhoea, rectal bleeding and weight loss. Sometimes it may lead to severe health complications resulting in death of an individual. Current research efforts to highlight the role of melatonin in regulating EZH2, a master epigenetic regulator and its beneficiary effect in case of IBD management.