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Papers of the Week

2022 May-Jun

AACE Clin Case Rep



Complicated Clinical Course in Incipient Gigantism Due to Treatment-resistant Aryl Hydrocarbon Receptor-Interacting Protein-mutated Pediatric Somatotropinoma.


van Santen S S, Daly AF, Buchfelder M, Coras R, Zhao Y, Beckers A, van der Lely A J, Hofland LJ, Balvers RK, van Koetsveld P, van den Heuvel-Eibrink M M, Neggers S J C M M
AACE Clin Case Rep. 2022 May-Jun; 8(3):119-123.
PMID: 35602875.


Our objective was to describe the clinical course and treatment challenges in a very young patient with a pituitary adenoma due to a novel gene mutation, highlighting the limitations of somatostatin receptor immunohistochemistry to predict clinical responses to somatostatin analogs in acromegaly.