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Papers of the Week

2022 May

Brain Nerve



[Intractable Orthostatic Hypotension in Patients with Parkinson’s Disease: Early Diagnosis and Treatment Strategies].


Orthostatic hypotension (OH) is a common non-motor symptom that occurs in Parkinson's Disease (PD) patients. Typical symptoms of OH are lightheadedness, visual disturbance, and fainting; however, nonspecific symptoms such as dizziness, headache, and fatigue are observed in mild cases. Although OH is prevalent in PD patients, it is often overlooked. Further, after diagnosis, the causative drug should be discontinued and non-pharmacological therapy should be performed,; however, if it is ineffective, additional pharmacological therapy should be administered depending on the symptom severity. The symptoms are usually progressive without proper intervention, and motor functions are affected leading to an increased risk of fainting and falls. Early diagnosis and intervention for OH improves the quality of life and prevents complications in PD patients.