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Papers of the Week

2022 Apr

Ann Transl Med



The diagnostic value of endoplasmic reticulum stress-related specific proteins GRP78 and CHOP in patients with sepsis: a diagnostic cohort study.


Li F, Lin Q, Shen L, Zhang Z, Wang P, Zhang S, Xing Q, Xia Z, Zhao Z, Zhang Y, Zhu B
Ann Transl Med. 2022 Apr; 10(8):470.
PMID: 35571390.


Sepsis is a life-threatening disease with high mortality. Early diagnosis is critical as early treatment improves outcomes. The protein levels of glucose regulated protein 78 (GRP78) and C/EBP homologous protein (CHOP), markers of endoplasmic reticulum stress (ERS) activation, were reported increasing rapidly and continuously in the serum of patients with sepsis. Therefore, they might serve as a potential biomarker for sepsis diagnosis. This study aimed to analyze the role of GRP78 and CHOP in the diagnosis of patients with sepsis.