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Papers of the Week

Papers: 14 May 2022 - 20 May 2022

Animal Studies


2022 Apr

Ann Transl Med



Does fructose have a protective role on migraine?-experimental evidence in a rat model of metabolic syndrome under omega-3 supplementation.


Barbosa IR, da Cunha G, Silva RBM, Freitas RDS, Dagnino APA, Campos MM
Ann Transl Med. 2022 Apr; 10(8):435.
PMID: 35571449.


Migraine is a highly disabling disease, for which current therapies are limited to symptom alleviation. There is compelling evidence linking migraine with metabolic disorders, but the causal relationship is not clear. Omega-3 (n-3) fatty acids have anti-inflammatory properties, with clear benefits in metabolic disorders, but its effects on migraine remains to be tested. We hypothesized that fructose-induced metabolic syndrome could aggravate migraine by increasing neuroinflammation and that n-3 treatment could mitigate it.