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Papers of the Week

2022 May 13

J Stroke Cerebrovasc Dis



Migraine-associated common genetic variants confer greater risk of posterior vs. anterior circulation ischemic stroke☆.


Frid P, Xu H, Mitchell BD, Drake M, Wasselius J, Gaynor B, Ryan K, Giese AK, Schirmer M, Donahue KL, Irie R, Bouts MJRJ, McIntosh EC, Mocking SJT, Dalca AV, Giralt-Steinhauer E, Holmegaard L, Jood K, Roquer J, Cole JW, et al.
J Stroke Cerebrovasc Dis. 2022 May 13; 31(8):106546.
PMID: 35576861.


To examine potential genetic relationships between migraine and the two distinct phenotypes posterior circulation ischemic stroke (PCiS) and anterior circulation ischemic stroke (ACiS), we generated migraine polygenic risk scores (PRSs) and compared these between PCiS and ACiS, and separately vs. non-stroke control subjects.