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Papers of the Week

Papers: 14 May 2022 - 20 May 2022

Human Studies

2022 May 09

Int J Mol Sci



Topical Capsaicin in Poly(lactic-co-glycolic)acid (PLGA) Nanoparticles Decreases Acute Itch and Heat Pain.


Malewicz NM, Rattray Z, Oeck S, Jung S, Escamilla-Rivera V, Chen Z, Tang X, Zhou J, Lamotte RH
Int J Mol Sci. 2022 May 09; 23(9).
PMID: 35563669.


Capsaicin, the hot pepper agent, produces burning followed by desensitization. To treat localized itch or pain with minimal burning, low capsaicin concentrations can be repeatedly applied. We hypothesized that alternatively controlled release of capsaicin from poly(lactic-co-glycolic acid) (PLGA) nanoparticles desensitizes superficially terminating nociceptors, reducing burning.