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Papers of the Week

Papers: 14 May 2022 - 20 May 2022

2022 May


36 Suppl 1

Sexually Dimorphic Effects of Nociceptor LKB1 on Mitochondrial Metabolism and Mechanical Allodynia After Fasting.


Pain induces metabolic stress in pain sensing neurons (nociceptors); alleviating this stress represents an avenue for treating pain. Liver kinase B1 (LKB1) is involved in maintaining energy homeostasis and is a key mediator of the cellular response to metabolic stress. If cellular energy modulation and pain relief is LKB1-dependent, then its removal could lead to metabolic imbalance and innocuous stimuli becoming painful (allodynia).