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Papers of the Week


2022 May


FASEB J


36 Suppl 1

Endometriosis Induces Colonic Inflammation and Reactive Gliosis in an Animal Model.

Authors

Rivera-Arce LA, Rodriguez-Cintron U, Cruz ML, Appleyard CB
FASEB J. 2022 May; 36 Suppl 1.
PMID: 35553953.

Abstract

Endometriosis is a complex gynecological disorder characterized by the ectopic growth of endometrial tissue. Symptoms of endometriosis are known to impair the quality of life of patients, among these symptoms are dysmenorrhea, chronic pelvic pain, and gastrointestinal (GI) issues. These GI issues are one of the common reasons for misdiagnosis with irritable bowel syndrome (IBS), a pain syndrome characterized by abdominal pain, painful bowel movements, diarrhea, and constipation, all of which are often present in endometriosis and persist even after treatment. Enteric glial cells (EGC) are known to play a role in pain associated with IBS, and reactive gliosis has been reported in patients with IBS, but the role of EGC in endometriosis has yet to be elucidated.