Papers of the Week

Based on global burden of headache reports, migraine is a prevalent disorder that affect approximately 15% of the adult population. Generally migraine attacks are sporadic, however, some individuals develop a chronic disease form. To date, several researches have shown that migraine is associated with some gastrointestinal disorders such as Helicobacter pylori (HP) infection, irritable bowel syndrome (IBS), and celiac disease (CD). However, the mechanisms explaining how the gut and the brain may interact in patients with migraine are not entirely clear. In this study, we aimed to evaluate the role of the short-chain fatty acids (SCFAs), such as sodium propionate (SP) and sodium butyrate (SB) as mediators and modulators of host intestinal microbial ecology, in regulating the pathophysiology of migraine in a mouse model induced by nitroglycerine (NTG).