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Papers of the Week

Papers: 14 May 2022 - 20 May 2022

Human Studies

2022 May-Jun

Pain Rep



Conditioned pain modulation is associated with heightened connectivity between the periaqueductal grey and cortical regions.


Harrison R, Gandhi W, van Reekum CM, Salomons TV
Pain Rep. 2022 May-Jun; 7(3):e999.
PMID: 35558091.


Conditioned pain modulation (CPM) is a psychophysical assessment used to estimate the efficiency of an individual's endogenous modulatory mechanisms. Conditioned pain modulation has been used as a predictive assessment for the development of chronic pain and responses to pain interventions. Although much is known about the spinal cord mechanisms associated with descending pain modulation, less is known about the contribution of supraspinal and especially cortical regions.