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Papers of the Week


2022 May


FASEB J


36 Suppl 1

Impaired mechanotransduction of small cerebral arteries after traumatic brain injury. Role of arachidonic acid pathway dysfunction.

Authors

Koller A, Szenasi A, Amrein K, Czeiter E, Szarka N, Toth P
FASEB J. 2022 May; 36 Suppl 1.
PMID: 35560418.

Abstract

Healthy functioning of the brain requires a precise autoregulation of cerebral blood flow, which in part is achieved by the pressure and flow sensitive vasomotor mechanisms. Traumatic brain injury (TBI) frequently occurs worldwide, resulting in brain diseases with high morbidity and mortality. Here, we hypothesized that TBI impairs the autoregulatory mechanisms, namely the pressure- and flow-induced constrictions of isolated rat middle cerebral arteries (MCAs).