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Papers of the Week

Papers: 14 May 2022 - 20 May 2022

Animal Studies, Pharmacology/Drug Development

2022 May


36 Suppl 1

miR-106b-25 Dysregulation in Complex Regional Pain Syndrome Contributes to T Cell Dysfunction.


Wickman J, Shenoda B, Van Duyne R, Klase Z, Ajit S
FASEB J. 2022 May; 36 Suppl 1.
PMID: 35560678.


Complex regional pain syndrome (CRPS) is a debilitating chronic pain disorder with no effective treatments. Growing evidence implicates aberrant immune regulation in the skin and T cell dysfunction in CRPS pathology. MicroRNA (miRNA) show promise in identifying biomarkers and disease mechanisms. miRNA cluster miR-106b-25 is dysregulated in CRPS patient whole blood and serum derived small extracellular vesicles (sEVs) compared to healthy controls. miR-106b-25 members are predicted to target several immune genes related to T cell function including CD69. We hypothesize that miR-106b-25 cluster plays a role in T-cell dysfunction by regulating members of CD69 signaling pathway. Here we examine miR-106b-25 mediated signaling in sEVs, whole blood, and skin from the tibia fracture model (TFM) of CRPS.