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Papers of the Week

Papers: 7 May 2022 - 13 May 2022

2022 May 10

Can J Anaesth

Effect of intravenous acetaminophen on postoperative outcomes in hip fracture patients: a systematic review and narrative synthesis.


Cho J S H, McCarthy K, Schiavo S, Jacob B, Engelsakis M, Zywiel M, Karkouti K, McCluskey S, Clarke H, Wong J
Can J Anaesth. 2022 May 10.
PMID: 35534770.


Hip fractures are debilitating in older adults because of their impact on quality of life. Opioids are associated with adverse effects in this population, so oral acetaminophen is commonly prescribed to minimize opioid use. Intravenous (iv) acetaminophen has been reported to have superior efficacy and bioavailability than oral acetaminophen. Nevertheless, its effect on postoperative outcomes in emergency hip fractures is unclear. This systematic review assessed the effect of iv acetaminophen on postoperative outcomes in older hip fracture patients.