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Papers of the Week

Papers: 7 May 2022 - 13 May 2022

2022 Apr 29

J Neurosurg

Idiopathic Parkinson’s disease and chronic pain in the era of deep brain stimulation: a systematic review and meta-analysis.


Flouty O, Yamamoto K, Germann J, Harmsen IE, Jung H H, Cheyuo C, Zemmar A, Milano V, Sarica C, Lozano AM
J Neurosurg. 2022 Apr 29:1-10.
PMID: 35535836.


Pain is the most common nonmotor symptom of Parkinson's disease (PD) and is often undertreated. Deep brain stimulation (DBS) effectively mitigates the motor symptoms of this multisystem neurodegenerative disease; however, its therapeutic effect on nonmotor symptoms, especially pain, remains inconclusive. While there is a critical need to help this large PD patient population, guidelines for managing this significant disease burden are absent. Herein, the authors systematically reviewed the literature and conducted a meta-analysis to study the influence of traditional (subthalamic nucleus [STN] and globus pallidus internus [GPi]) DBS on chronic pain in patients with PD.