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Papers: 7 May 2022 - 13 May 2022


2022 May 10

Eur J Pain

Temporal properties of pain contrast enhancement using repetitive stimulation.


Szikszay TM, Adamczyk WM, Lévénez JLM, Gouverneur P, Luedtke K
Eur J Pain. 2022 May 10.
PMID: 35535976.


Offset analgesia (OA) is characterized by a disproportionately large reduction in pain following a small decrease in noxious stimulation and is based on temporal pain contrast enhancement (TPCE). The underlying mechanisms of this phenomenon are still poorly understood. This study is aiming to investigate whether TPCE can also be induced by repetitive stimulation, i.e., by stimuli clearly separated in time.