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Papers of the Week

2022 May 05

Can J Anaesth

Peak plasma concentration of total and free bupivacaine after erector spinae plane and pectointercostal fascial plane blocks.


Maximos S, Vaillancourt-Jean É, Mouksassi S, De Cassai A, Ayoub S, Ruel M, Desroches J, Hétu P-O, Moore A, Williams S
Can J Anaesth. 2022 May 05.
PMID: 35513684.


Erector spinae plane blocks (ESPB) and pectointercostal fascial (PIFB) plane blocks are novel interfascial blocks for which local anesthetic (LA) doses and concentrations necessary to achieve safe and effective analgesia are unknown. The goal of this prospective observational study was to provide the timing (T) and concentration (C) of maximum total and free plasma bupivacaine after ESPB in breast surgery and after PIFB in cardiac surgery patients.