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Papers of the Week

Papers: 7 May 2022 - 13 May 2022

Human Studies

2022 May 03


Tonic pain alters functional connectivity of the descending pain modulatory network involving amygdala, periaqueductal gray, parabrachial nucleus and anterior cingulate cortex.


Meeker TJ, Schmid A-C, Keaser ML, Khan SA, Gullapalli RP, Dorsey SG, Greenspan JD, Seminowicz DA
Neuroimage. 2022 May 03:119278.
PMID: 35523367.


Resting state functional connectivity (FC) is widely used to assess functional brain alterations in patients with chronic pain. However, reports of FC accompanying tonic pain in pain-free persons are rare. A network we term the Descending Pain Modulatory Network (DPMN) is implicated in healthy and pathologic pain modulation. Here, we evaluate the effect of tonic pain on FC of specific nodes of this network: anterior cingulate cortex (ACC), amygdala (AMYG), periaqueductal gray (PAG), and parabrachial nuclei (PBN).