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Papers of the Week

Papers: 30 Apr 2022 - 6 May 2022


Human Studies, Pharmacology/Drug Development

2022 May 05

Brain Behav

Lithium use associated with symptom severity in comorbid bipolar disorder I and migraine.


Sekula NM, Yocum AK, Anderau S, McInnis MG, Marshall DF
Brain Behav. 2022 May 05:e32585.
PMID: 35510536.


Bipolar disorder (BD) and migraine headaches are frequently comorbid. The common etiological features are unknown, however cortical hyperexcitability (EEG) of migraines, and the report of hyperexcitability in pluripotent stem cell-derived neurons from lithium responsive BD subjects offers a physiological hypothesis of excitable neurons linking these disorders. However, clinical studies suggest that a history of migraine is associated with higher rates of relapse in those with BD taking lithium. Lithium use and history of migraine in this prospective longitudinal study of BD find that lithium use is associated with a greater symptom severity in BD.