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Papers of the Week

2022 Spring

Iran J Child Neurol



A case report of Posterior reversible encephalopathy syndrome with spinal cord involvement (PRES-SCI) as an atypical presentation of PRES in children: A case report and review of the literature.


Akhondian J, Ashrafzadeh F, Seilanian Toosi F, Behnam M, Beiraghi Toosi M, Imannezhad S, Akhoundian M R, Hashemi N
Iran J Child Neurol. 2022 Spring; 16(2):149-154.
PMID: 35497107.


Posterior reversible encephalopathy syndrome (PRES) has a broad spectrum of clinical presentations and radiological features. Diagnosis of PRES is established based on reversible clinical manifestations and sequential neuroimaging findings. Atypical MRI features include hemorrhage, restricted diffusion or contrast enhancement of lesions, and involvement of the temporal and frontal lobes, brainstem, basal ganglia, corpus callosum, cerebellum, and spine. Atypical PRES, with or without spinal cord involvement, is a rare presentation, especially in children. Until 2020, only five cases of PRES with spinal cord involvement (PRES-SCI) were reported in the pediatric population.