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Papers of the Week
Modulation of the kappa and mu opioid axis for the treatment of chronic pruritus: A review of basic science and clinical implications.
Abstract
Treating chronic pruritus is challenging for dermatologists due to the lack of therapeutic options. We review the effects of κ-opioid receptor (KOR) and μ-opioid receptor (MOR) in the modulation of itch, summarize evidence supporting the efficacy and safety of opioid receptor-targeting agents in chronic pruritus, and address clinical considerations.