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Papers of the Week

2022 Apr 27

Rev Med Suisse



[Cramps and fasciculations: is it amyotrophic lateral sclerosis?]


Hübers A, Fayolle D, Ochsner F, Echaniz-Laguna A, Magy L, Vicino A, Théaudin M
Rev Med Suisse. 2022 Apr 27; 18(779):790-793.
PMID: 35481502.


Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease of the adult age. It is an aggressive condition with a mean disease duration of only 3 to 5 years, characterized by progressive weakness and atrophy of limb, bulbar, and respiratory muscles. In general, death is caused by chronic hypoventilation due to respiratory insufficiency. No causal treatment is known today, but the two therapeutic agents authorized in Switzerland for the treatment of ALS can slow disease progression significantly. Other important therapeutic strategies include invasive/non-invasive ventilation, pain therapy, as well as physio-, ergo- and speech therapy on a regular basis.