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PLoS One



Development of a conceptual model for evaluating new non-curative and curative therapies for sickle cell disease.


Johnson KM, Jiao B, Bender MA, Ramsey SD, Devine B, Basu A
PLoS One. 2022; 17(4):e0267448.
PMID: 35482721.


Sickle cell disease (SCD) is a clinically heterogeneous disease with many acute and chronic complications driven by ongoing vaso-occlusion and hemolysis. It causes a disproportionate burden on Black and Hispanic communities. Our objective was to follow the SMDM/ISPOR Task Force recommendations for good practices and create a conceptual model of the progression of SCD under current clinical practice to inform cost-effectiveness analyses (CEA) of promising curative therapies in the pipeline over a lifetime horizon.