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Papers of the Week

Papers: 30 Apr 2022 - 6 May 2022

Human Studies

2022 Apr 29

J Headache Pain



Central effects of galcanezumab in migraine: a pilot study on Steady State Visual Evoked Potentials and occipital hemodynamic response in migraine patients.


De Tommaso M, La Rocca M, Quitadamo S G, Ricci K, Tancredi G, Clemente L, Gentile E, Ammendola E, Delussi M
J Headache Pain. 2022 Apr 29; 23(1):52.
PMID: 35484504.


The discovery of the prominent action of Calcitonin Gene Related Peptide -CGRP- on trigeminal afferents and meningeal vessels, opened a new era in migraine treatment. However, how the block of nociceptive afferents could act on central mechanisms of migraine is still not clear. In this pilot study we aimed to test the effect of 3 months Galcanezumab (CGA) therapy on occipital visual reactivity in migraine patients, using the Steady State Visual Evoked Potentials-SSVEPs and Functional Near Infrared Spectroscopy -fNIRS.