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Papers of the Week

Papers: 30 Apr 2022 - 6 May 2022

2022 Apr 28

Bioelectron Med



Sex-specific differences in the efficacy of traditional low frequency versus high frequency spinal cord stimulation for chronic pain.


Conic R R, Caylor J, Cui CL, Reyes Z, Nelson E, Yin S, Lerman I
Bioelectron Med. 2022 Apr 28; 8(1):8.
PMID: 35484578.


Spinal cord stimulation (SCS), an FDA-approved therapy for chronic pain, uses paresthesia (low frequency SCS (LF-SCS)) or paresthesia-free (such as high-frequency SCS (HF-SCS)) systems, providing analgesia through partially-elucidated mechanisms, with recent studies indicating a sexual dimorphism in pain pathogenesis (Bretherton et al., Neuromodulation, 2021; Paller et al., Pain Med 10:289-299, 2009; Slyer et al., Neuromodulation, 2019; Van Buyten et al., Neuromodulation 20:642-649, 2017; Mekhail et al., Pain Pract, 2021). We aim to evaluate SCS therapy sex effects based on paradigm, utilizing visual analog scores (VAS), perceived pain reduction (PPR), and opioid use.