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Papers of the Week

Papers: 30 Apr 2022 - 6 May 2022

Pharmacology/Drug Development

2022 Apr 29

Br J Pharmacol

Design and development of novel, short, stable dynorphin-based opioid agonists for safer analgesic therapy.


Lohman R-J, Tupally K R, Kandale A, Cabot PJ, Parekh HS
Br J Pharmacol. 2022 Apr 29.
PMID: 35485985.


The kappa opioid receptor has exceptional potential as an analgesic target, seemingly devoid of the many peripheral side-effects of Mu opioid receptors. Kappa-selective, small molecule pharmaceutical agents have been developed, but centrally-mediated side effects have limited their clinical translation. Here, we modify an active endogenous dynorphin peptide to improve drug-likeness and develop safer KOPr agonists for clinical use.