I am a
Home I AM A Search Login

Papers of the Week

Papers: 23 Apr 2022 - 29 Apr 2022

2022 Apr 01

JAMA Netw Open



Association of Opioid Dose Reduction With Opioid Overdose and Opioid Use Disorder Among Patients Receiving High-Dose, Long-term Opioid Therapy in North Carolina.


DiPrete BL, Ranapurwala SI, Maierhofer CN, Fulcher N, Chelminski PR, Ringwalt CL, Ives TJ, Dasgupta N, Go VF, Pence BW
JAMA Netw Open. 2022 Apr 01; 5(4):e229191.
PMID: 35476064.


Rapid reduction or discontinuation of long-term opioid therapy may increase risk of opioid overdose or opioid use disorder (OUD). Current guidelines for chronic pain management caution against rapid dose reduction but are based on limited evidence.