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Papers of the Week

Papers: 23 Apr 2022 - 29 Apr 2022

2022 Apr 23

Eur J Pediatr

A therapeutic guide on pediatric irritable bowel syndrome and functional abdominal pain-not otherwise specified.


Rexwinkel R, Vlieger AM, Saps M, Tabbers MM, Benninga MA
Eur J Pediatr. 2022 Apr 23.
PMID: 35460383.


Disorders of the gut-brain interaction negatively impact quality of life and carry a substantial socioeconomic burden. Irritable bowel syndrome (IBS) and functional abdominal pain-not otherwise specified (FAP-NOS) are common functional abdominal pain disorders in childhood. The pathophysiology is not fully understood, and high-quality intervention trials and international guidelines are missing. Therefore, the management of these disorders remains challenging. This review aims to provide an up-to-date overview of therapeutic possibilities for pediatric IBS or FAP-NOS and recommends management strategies. To prevent unnecessary referrals and extensive costs, it is fundamental to make a positive diagnosis of IBS or FAP-NOS in children with chronic abdominal pain with only minimal investigations. A tailor-made approach for each patient, based on the accompanying physical and psychological symptoms, is proposed to date.