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Papers of the Week


2022 Apr 21


Clin Drug Investig

Prevalence of Gabapentinoids and Central Nervous System Depressant Drugs, and Their Association with Risk Factors for Respiratory Depression in Primary Care Patients.

Authors

Fernández-Liz E, Barceló-Colomer M E, Gómez-Ganda L, Varon-Galcera C, Lalueza-Broto P, Medel-Rebollo F J, Hortelano-García M A, Martín-Gracia E
Clin Drug Investig. 2022 Apr 21.
PMID: 35446006.

Abstract

Warnings have been published regarding an increased risk of severe respiratory depression in patients receiving gabapentinoids either alone or in combination with opioids and/or anxiolytics/hypnotics, especially in individuals with a respiratory risk factor. The aim is to report the prevalence of the use of gabapentinoids alone and associated with central nervous system depressant drugs, and possible associated risk factors for respiratory depression, in order to identify the most fragile population and establish intervention strategies.