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Papers of the Week

Papers: 23 Apr 2022 - 29 Apr 2022

Human Studies, Pharmacology/Drug Development

2022 Apr 22

PLoS Med



Brain-based measures of nociception during general anesthesia with remifentanil: A randomized controlled trial.


Karunakaran K D, Kussman BD, Peng K, Becerra L, Labadie R, Bernier R, Berry D, Green S, Zurakowski D, Alexander ME, Borsook D
PLoS Med. 2022 Apr 22; 19(4):e1003965.
PMID: 35452458.


Catheter radiofrequency (RF) ablation for cardiac arrhythmias is a painful procedure. Prior work using functional near-infrared spectroscopy (fNIRS) in patients under general anesthesia has indicated that ablation results in activity in pain-related cortical regions, presumably due to inadequate blockade of afferent nociceptors originating within the cardiac system. Having an objective brain-based measure for nociception and analgesia may in the future allow for enhanced analgesic control during surgical procedures. Hence, the primary aim of this study is to demonstrate that the administration of remifentanil, an opioid widely used during surgery, can attenuate the fNIRS cortical responses to cardiac ablation.