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Papers of the Week
P2X Receptor Antagonists and their Potential as Therapeutics: a patent review (2010 – 2021).
Authors
Abstract
: Purinergic receptors play a critical role in neurotransmission, and modulation of complex physiological functions. As such, they have been implicated in numerous disease states including chronic pain, inflammation, autoimmune disease, and cancer. The past decade has seen substantial progress in the design of novel chemical compounds that act on the P2X class of receptors and warrants an updated review of this field.