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Papers of the Week

Papers: 16 Apr 2022 - 22 Apr 2022

Human Studies, Pharmacology/Drug Development


Front Neurol


Plasma Levels of CGRP During a 2-h Infusion of VIP in Healthy Volunteers and Patients With Migraine: An Exploratory Study.


Pellesi L, Al-Karagholi M A-M, De Icco R, Chaudhry B A, Lopez C L, Snellman J, Hannibal J, Amin F M, Ashina M
Front Neurol. 2022; 13:871176.
PMID: 35432170.


The activation of perivascular fibers and the consequent release of vasoactive peptides, including the vasoactive intestinal polypeptide (VIP), play a role in migraine pathogenesis. A 2-h infusion of VIP provoked migraine, but the mechanisms remain unknown. We investigated whether 2-h infusion of VIP caused alterations in plasma levels of the calcitonin gene-related peptide (CGRP) and whether any changes might be related to the induced migraine attacks.