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Papers of the Week

Papers: 16 Apr 2022 - 22 Apr 2022

2022 Apr 14

Curr Rheumatol Rep

Autonomic Nervous System Dysregulation and Osteoarthritis Pain: Mechanisms, Measurement, and Future Outlook.


Yeater TD, Cruz CJ, Cruz-Almeida Y, Allen KD
Curr Rheumatol Rep. 2022 Apr 14.
PMID: 35420372.


The autonomic nervous system is an important regulator of stress responses and exhibits functional changes in chronic pain states. This review discusses potential overlap among autonomic dysregulation, osteoarthritis (OA) progression, and chronic pain. From this foundation, we then discuss preclinical to clinical research opportunities to close gaps in our knowledge of autonomic dysregulation and OA. Finally, we consider the potential to generate new therapies for OA pain via modulation of the autonomic nervous system.