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Papers of the Week

2022 Mar

J Clin Biochem Nutr



A questionnaire-based survey on the etiopathogenesis of chronic constipation during a medical check-up in Japan.


Otani K, Watanabe T, Takahashi K, Ominami M, Nadatani Y, Fukunaga S, Hosomi S, Kamata N, Tanaka F, Nagami Y, Taira K, Kimura T, Fukumoto S, Fujiwara Y
J Clin Biochem Nutr. 2022 Mar; 70(2):205-211.
PMID: 35400826.


The study group of the Japanese Society of Gastroenterology released evidence-based clinical practice guidelines for chronic constipation (CC) in 2017, and irritable bowel syndrome (IBS) was treated as one of the causes of CC. We examined the differences in characteristics between IBS and non-IBS subjects with CC who underwent a medical check-up in Japan. A total of 10,658 subjects participated in this study, and we focused on 467 subjects who fulfilled the diagnostic criteria of CC using a questionnaire survey. The number of IBS subjects was 21, and they had sleep disorders, were more symptomatic (e.g., abdominal pain, abdominal bloating/distension, feeling stressed, annoyance, lack of motivation, fatigue upon waking, and feeling depressed), and had more episodes of sensation of incomplete evacuation and anorectal obstruction/blockage during defecation than non-IBS subjects. Furthermore, stool frequency of IBS subjects was significantly different from non-IBS subjects. Multivariate ordinal logistic regression analysis revealed that the factors associated with a higher stool frequency were IBS [odds ratio (OR), 2.46; 95% confidence interval (CI), 1.00-6.05;  = 0.049], male sex (OR, 1.97; 95% CI, 1.20-3.23;  = 0.007), and regular exercise (OR, 1.80; 95% CI, 1.05-3.07;  = 0.033). These findings suggest that IBS has unique characteristics in subjects with CC.