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Papers of the Week

2022 Apr 10

Palliat Med

Pharmacovigilance in hospice/palliative care: Net effect of amitriptyline or nortriptyline on neuropathic pain: UTS/IMPACCT Rapid programme international consecutive cohort.


Hussein A, Digges M, Chang S, Hunt J, Doogue M, Rowett D, Agar M, Sinnarajah A, Kain D, Allan S, Boland JW, Currow DC
Palliat Med. 2022 Apr 10:2692163221085855.
PMID: 35403513.


Real-world effectiveness of interventions in palliative care need to be systematically quantified to inform patient/clinical decisions. Neuropathic pain is prevalent and difficult to palliate. Tricyclic antidepressants have an established role for some neuropathic pain aetiologies, but this is less clear in palliative care.