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Papers of the Week


2022 Apr 07


N Engl J Med


386


14

Oral Tebipenem Pivoxil Hydrobromide in Complicated Urinary Tract Infection.

Authors

Eckburg PB, Muir L, Critchley IA, Walpole S, Kwak H, Phelan A-M, Moore G, Jain A, Keutzer T, Dane A, Melnick D, Talley AK
N Engl J Med. 2022 Apr 07; 386(14):1327-1338.
PMID: 35388666.

Abstract

There is a need for oral antibiotic agents that are effective against multidrug-resistant gram-negative uropathogens. Tebipenem pivoxil hydrobromide is an orally bioavailable carbapenem with activity against uropathogenic Enterobacterales, including extended-spectrum beta-lactamase-producing and fluoroquinolone-resistant strains.