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Papers of the Week

2022 04 05

J Am Acad Orthop Surg Glob Res Rev



Meloxicam versus Celecoxib for Postoperative Analgesia after Total Knee Arthroplasty: Safety, Efficacy and Cost.


Haffar A, Fillingham YA, Breckenridge L, Gursay D'A, Lonner JH
J Am Acad Orthop Surg Glob Res Rev. 2022 04 05; 6(4).
PMID: 35389917.


Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used as part of multimodal analgesia in total knee arthroplasty (TKA). Selective cyclooxygenase (COX)-2 inhibitors (e.g., celecoxib) are believed to have fewer gastrointestinal (GI) adverse effects than nonselective NSAIDS. Meloxicam is less selective for COX-2 than celecoxib is and partially inhibits COX-1 at higher doses. Nonetheless, some surgeons prefer using nonselective NSAIDs because of their lower expense.