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Papers of the Week

Papers: 9 Apr 2022 - 15 Apr 2022

Pharmacology/Drug Development


Front Integr Neurosci


Immunoregulatory Effect of Preventive Supplementation of Omega-3 Fatty Acid in a Complex Regional Pain Syndrome Type I Model in Mice.


Fernandes P F, de Galassi T O, Horewicz V V, Salgado A S I, Mack J M, Baldança H D S, Ferreira da Silva A P, Bruehl S, Bittencourt EB, Seim LA, Martins D F, Bobinski F
Front Integr Neurosci. 2022; 16:818692.
PMID: 35391753.


Complex regional pain syndrome (CRPS) is usually triggered by trauma or a surgical procedure, and it typically becomes an established one after an intense inflammatory process with chronic pain and edema as the main symptoms. Available treatments for CRPS have low efficacy. This study aimed to evaluate the clinical and immunoregulatory effects of omega-3 polyunsaturated fatty acid (PUFA) supplementation on paw edema and anti- and pro-inflammatory cytokines and macrophage phenotypes in the chronic post-ischemia pain (CPIP) preclinical model of CRPS-Type I.