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Papers of the Week

2022 Jan-Mar

Dose Response



Osthole-Mediated Inhibition of Neurotoxicity Induced by Ropivacaine via Amplification of the Cyclic Adenosine Monophosphate Signaling Pathway.


Wang WB, Zhou H, Sun LB, Li MN, Gao FJ, Sun AJ, Zou X
Dose Response. 2022 Jan-Mar; 20(1):15593258221088092.
PMID: 35392264.


Ropivacaine is widely used for clinical anesthesia and postoperative analgesia. However, the neurotoxicity induced by ropivacaine in a concentration- and duration-dependent manner, and it is difficult to prevent neurotoxicity. Osthole inhibits phosphodiesterase-4 activity by binding to its catalytic site to prevent cAMP hydrolysis. The aim of this present study is to explore the precise molecular mechanism of osthole-mediated inhibition of neurotoxicity induced by ropivacaine.