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Papers of the Week

2022 Mar 18

Int J Obstet Anesth


IL-1ra polymorphisms and risk of epidural-related maternal fever (EPIFEVER-2): study protocol for a multicentre, observational mechanistic cohort study.


Ali A, Weber V, Thompson SJ, Abbott TEF, Harmston R, David AL, Ackland GL
Int J Obstet Anesth. 2022 Mar 18; 50:103540.
PMID: 35395614.


Laboratory data suggest that insufficient circulating levels of the anti-inflammatory cytokine interleukin-1 receptor antagonist (IL-1ra) are associated with intrapartum inflammation and epidural-related maternal fever, both of which increase the rate of obstetric interventions and antibiotic use during labour. Genetic polymorphisms strongly influence IL-1ra levels in the general population. We aim to examine the association between IL-1ra polymorphisms and epidural-related maternal fever using Mendelian randomization analysis.