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Papers of the Week

Papers: 2 Apr 2022 - 8 Apr 2022

Animal Studies, Pharmacology/Drug Development

2022 Apr 01

Neurosci Lett


Calcitonin gene-related peptide is not involved in neuropathic pain induced by partial sciatic nerve ligation in mice.


Ishida K, Tanaka S, Shen D, Matsui S, Fuseya S, Shindo T, Kawamata M
Neurosci Lett. 2022 Apr 01; 778:136615.
PMID: 35367570.


Optimal neuropathic pain (NeP) therapy has still not been established despite great efforts to develop new strategies for NeP analgesia. One possible target might be calcitonin gene-related peptide (CGRP). This is because the expression of CGRP and its receptors in the dorsal horn of the spinal cord might be associated with the persistence of pain symptoms including symptoms of NeP. We previously developed αCGRP knockout mice, and we aimed in this study to clarify the roles of CGRP in NeP by partial sciatic nerve ligation (PSNL) using the knockout mice.